(CNN) -- They're ready to sting, and they know where they're going.
MIT postdoctoral fellow Abigail Lytton-Jean explains machinery for making nanoparticle materials.
They're called "nanobees," and they're not insects -- they're tiny particles designed to destroy cancer cells by delivering a synthesized version of a toxin called melittin that is found in bees.
"Melittin, which would otherwise result in substantial destruction of your red blood cells and other normal tissues if it were delivered intravenously alone, is completely safe when it's on a nanoparticle," said Dr. Samuel Wickline, director of the Siteman Center of Cancer Nanotechnology Excellence at Washington University in St. Louis, Missouri.
Nanobees are one of the latest examples of how nanotechnology may change the way diseases are treated.
Nanotechnology encompasses a wide array of innovations that make use of structures that are 100 nanometers or smaller. That means they generally cannot be seen under a regular microscope, but are larger than individual atoms. For example, a nanobee is less than 10 times the diameter of a red blood cell, Wickline said.
Particles on the nanoscale are small enough to enter cells, but big enough to carry large doses of drugs, said Robert Langer, Institute professor at the Massachusetts Institute of Technology and a leader in the nanotech field.
"We are gradually forming a pipeline of nanotechnology-based products," said Piotr Grodzinski, director of the National Cancer Institute's Alliance for Nanotechnology in Cancer, a program that funds eight Centers of CancerNanotechnology Excellence in the U.S., including Wickline's and Langer's research initiatives. "These things are happening as we speak."
There have already been two approved cancer treatments on the market that make use of nanoparticles: ovarian cancer drug Doxil, approved in 1995, and breast cancer drug Abraxane, approved in 2005. Both of these involve medication bound with nanoparticles that circulate in the bloodstream for longer than conventional drugs and are expected to migrate to the tumor site, Grodzinski said. These drugs are being tested in some of the eight clinical trials associated with the NCI nano program.
Nanobees, by contrast, are engineered to travel directly to tumor cells without harming any others. They leave the healthy cells alone because the blood vessels around a tumor are like a "postal address" for the nanobees, Wickline said. These vessels express a particular protein to which a substance on the nanobees has a chemical affinity.
This principle of targeting harmful cells and leaving healthy cells intact is under development in many labs. It means efficient delivery of large concentrations of drugs, but with fewer side effects, experts say. One hundred trillion nanobees can be delivered in a single dose, and are not difficult to make, Wickline said. Also, scientists do not use real insects, so they're "not decreasing the bee population," he said.
So far nanobees have been tested only on mice, with promising results, researchers said. Wickline anticipates this therapy could become widely available in humans in about five years.
Dr. Ellen Vitetta, who also works on targeted nanotech cancer therapies at the University of Texas Southwestern Medical Center at Dallas, found the approach intriguing, but said it will be at least 10 years before something like this gets to the market. That's because what works in mice doesn't always work in humans, as she learned while developing a targeted antibody cancer treatment.
"People need to appreciate the time issues and the cost issues and just what sort of tests need to be done," she said. "But it's always fun and exciting to see a new approach, because who knows what's going to end up at the finish line."
Langer estimates that his group's nanotechnology technique for prostate cancer could be in clinical trials by the middle of next year. The method involves putting an approved cancer drug, docetaxel, in a nanoparticle that has a homing device to take it directly to the tumor.
These nanoparticles are made out of some of the same materials often used for dissolvable sutures, Langer said. In addition to having an "affinity molecule," which targets the tumor cells, these nanoparticles are coated with polyethylene glycol, which helps the particle get to its target without being "eaten" by white blood cells called macrophages.
Langer and colleagues have also been involved in a new treatment for ovarian cancer, as described in this month's issue of the journal Cancer Research. The technique has shown success in mice, and could go into clinical trials within one to two years, said lead author Daniel Anderson at MIT. The group has published work on two methods, one using DNA and one using RNA. These particles do not have special targeting antibodies on them, but are injected straight into the abdominal cavity where the cancer cells are likely floating.
Other research groups are exploring the potential of carbon nanotubes, cylindrical carbon molecules that also have applications in electronics and other areas. Researchers led by Vitetta have developed a method of heating the nanotubes with infrared light, which then "cooked" and killed cancerous lymphoma cells.
Vitetta said she doesn't want to move this treatment forward into humans until the researchers have resolved a number of issues about its potential toxicity.
Nanoparticles are also useful in medical diagnosis, researchers have found. Abigail Lytton-Jean, a postdoctoral fellow in Langer's lab, worked at Northwestern University on showing that gold nanoparticles can help detect the presence of DNA. When the nanoparticles are coated with a DNA sequence, the solution changes color in the presence of the corresponding DNA. One possible application of this would be anthrax detection, she said.
While a lot of new research is ongoing with nano-sized materials, the particles themselves are not new, and therefore should not cause any more safety concerns than other materials used in medicine, experts say.
"There are going to be nanomaterials that are toxic for sure, but I definitely do not think that because something is nano there's any more reason to have alarm," Lytton-Jean said.
Many of the NCI-sponsored nano centers, located at universities across the country, have spun off small companies, Grodzinski said. Kerios, which will make the nanobees, and BIND, which will work on Langer's group's prostate cancer therapy, are two of the 25 companies that have arisen from the research.
The pharmaceutical giants, meanwhile, are watching what comes out of them, he said.
"They probably will acquire some of these companies," he said.
Welcome to The Hidden WikiNew hidden wiki url 2015 http://zqktlwi4fecvo6ri.onion Add it to bookmarks and spread it!!! Editor's picks
Bored? Pick a random page from the article index and replace one of these slots with it.
The Matrix - Very nice to read.
How to Exit the Matrix - Learn how to Protect yourself and your rights, online and off.
Verifying PGP signatures - A short and simple how-to guide.
In Praise Of Hawala - Anonymous informal value transfer system.
Here are five different things that you can help us out with.
Plunder other hidden service lists for links and place them here!
File the SnapBBSIndex links wherever they go.
Set external links to HTTPS where available, good certificate, and same content.
Care to start recording onionland's history? Check out Onionland's Museum Perform Dead Services Duties.
Introduction PointsAhmia.fi - Clearnet search engine for Tor Hidden Services (allows you to add new sites to its database).
DuckDuckGo - A Hidden S…
[SOLVED] IDM WAS REGISTERED WITH A FAKE SERIAL NUMBER Good News [May 08, 2015]: IDM developers got smarter, but the crackers are always a step ahead. Follow this article and send an email to email@example.com if you are desperate. I can NOT post any crack here for legal reasons. Happy Downloading with IDM. ;)
first tip is to use latest crack for idm from onhax.net idm universal web crack and make sure u are using all latest vers
I am sure many of us are too much dependent on Internet Download Manager a.k.a. IDM. The main reason didn’t permanently switch to linux was IDM. I mainly use it for batch downloading and download streaming videos.
Till yesterday, IDM was working fine with me (of course with fake serial numbers, keygen, crack, patch etc. which could be found with little effort).
But few days ago, with the latest update version 6.18 build 7 (released on Nov 09, 2013) Internet Download Manager was literally had a breakthrough and crushed all the serial numbers, …
Mouse, touchpad, and keyboard problems in Windows
This tutorial is designed to help you identify and fix common mouse, touchpad, and keyboard problems in Windows. It doesn't cover device problems related to specific programs.
Mouse, touchpad, and keyboard problems can have a number of causes:
Cables that aren't connected properly
Incorrect device settings
Corrupted or incompatible drivers
Many mouse, touchpad, and keyboard problems are caused by hardware that isn't set up properly. Here's some information about how to check your device, make sure cables are connected properly, make sure the hardware has power, and check the settings.
Make sure cables are connected properly
Check that all cables are plugged in to the correct locations. This can include mouse and keyboard, PS2 and USB cables, and, in some cases, external USB touchpad cables.
Disconnect USB cables and wait for a short time for the device drive…