Skip to main content

Menopausal Estrogen Therapy Doesn't Appear To Sharpen Women's Brains, No Matter When They Go On It

If you’re a postmenopausal women looking to keep your brain sharp (really, isn’t everyone?), a growing body of research shows that taking estrogen is probably not the way to go, even if you ask for a prescription as soon as your menstrual periods start to dwindle.
On the other hand, postmenopausal hormone therapy won’t dull your brain, either, according to a new study out this week. That’s reassuring for women who opt for estrogen to relieve symptoms such as hot flashes, which, along with prevention of osteoporosis, are the only Food and Drug Administration-approved reasons for going on the hormone.
The latest study on this topic, published online by the journalNeurology, investigated whether taking estrogen around the time of the menopause transition protects the brain, while going on it later doesn’t. The timing hypothesis has been circulating for at least a decade and a half or so, ever since the landmark Women’s Health Initiative (WHI) concluded that menopausal hormone therapy does not protect women against diseases of aging, such as heart attack, stroke or dementia, and, in s0me cases, might even increase women’s risk of them. As a result of the WHI, the proportion of postmenopausal women using estrogenplummeted, although millions still do.
Critics argued that most of the women in the WHI were too far past menopause to benefit from estrogen. The WHI had randomly assigned more than 27,000 women ages 50 to 79 to take either hormone pills or placebo pills. The majority were age 60 to 69, or roughly a decade to two decades past menopause.
Pfizer menopause drugs Premarin, right, and Prempro, which contain the hormone estrogen, sit on a pharmacy shelf. A new study confirms that going on estrogen after menopause does not help keep women’s brains sharp, no matter how long after menopause they start taking it. (Photographer: Daniel Acker/Bloomberg)
“The question about timing, I think, is legitimate,” Dr. Victor Henderson, lead author of the new study, told me. Estrogen affects a range of tissues, each of which has to be considered individually as far as the timing of treatment, said Henderson, a professor of health research and policy and of neurology and neurological sciences at Stanford University.
For example, Henderson and his collaborators reported in March in theNew England Journal of Medicine that estrogen had a beneficial effect on study participants’ hearts only in those who had started taking it within six years of menopause. On the other hand, he said, research has shown that estrogen helps strengthen bones but increases the risk of stroke no matter how long after menopause women begin taking it.
Henderson’s findings about hormone therapy and the brain, as well as the recent findings about the heart, come out of the “Early vs. Late Intervention Trial with Estradiol,” or ELITE. Designed to answer the question of whether the timing of hormone therapy makes a difference on any tissue, ELITE enrolled two groups of healthy women. One group was fewer than six years past menopause, while the other was a decade or more past menopause. They were randomly assigned to take pills containing estradiol, a different type of estrogen than the one used in the WHI, or placebo pills.
(Because taking estrogen alone is known to increase the risk of uterine cancer, women assigned to the estradiol pills who still had their uteri were also given a vaginal gel containing progestin, another hormone that counteracts estrogen’s effects on the uterus. Because the women  weren’t supposed to know whether they were taking estradiol or placebo pills, those with a uterus assigned to the placebo pills were also given a placebo vaginal gel.)

Comments

Popular posts from this blog

Hidden Wiki

Welcome to The Hidden WikiNew hidden wiki url 2015 http://zqktlwi4fecvo6ri.onion Add it to bookmarks and spread it!!!
Editor's picks Bored? Pick a random page from the article index and replace one of these slots with it.
The Matrix - Very nice to read. How to Exit the Matrix - Learn how to Protect yourself and your rights, online and off. Verifying PGP signatures - A short and simple how-to guide. In Praise Of Hawala - Anonymous informal value transfer system. Volunteer Here are five different things that you can help us out with.
Plunder other hidden service lists for links and place them here! File the SnapBBSIndex links wherever they go. Set external links to HTTPS where available, good certificate, and same content. Care to start recording onionland's history? Check out Onionland's Museum Perform Dead Services Duties. Introduction PointsAhmia.fi - Clearnet search engine for Tor Hidden Services (allows you to add new sites to its database). DuckDuckGo - A Hidden S…

Explainer: The nico-teen brain

Explainer: The nico-teen brain The adolescent brain is especially vulnerable to the addictive effects of nicotine BY  TERESA SHIPLEY FELDHAUSEN 7:00AM, AUGUST 19, 2015 Nicotine (black triangle towards center left) tricks the nerve cell (neuron) into sending a message to release more dopamine (yellow dots). Those molecules enter the space (synapse) between one nerve cell and the next. When they get picked up by neighboring cells, this gives users a feel-good high. It also creates the risk of addiction and other health problems.  EMail Print Twitter Facebook Reddit Google+ NATIONAL INSTITUTE ON DRUG ABUSE, ADAPTED BY J. HIRSHFELD Nicotine is the addictive chemical in tobacco smoke and e-cigarette vapors. And doctors say the teenage brain is no place for it to end up. Nicotine can reach the brain within seven seconds of puffing on a cigar, hookah, cigarette or electronic cigarette.
The area of the brain responsible for emotions and controlling our wild impulses is known as the prefrontal c…

fix idm integration on chrome

Chrome Browser IntegrationI do not see IDM extension in Chrome extensions list. How can I install it? 
How to configure IDM extension for Chrome?Please note that all IDM extensions that can be found in Google Store are fake and should not be used. You need to install IDM extension manually from IDM installation folder. Read in step 2 how to do it.

1. Please update IDM to the latest version by using "IDM Help->Check for updates..." menu item

2. I don't see "IDM Integration module" extension in the list of extensions in Chrome. How can I install it?

Press on Chrome menu (arrow 1 on the image), select "Settings" menu item (arrow 2 on the image) and then select "Extensions" tab (arrow 3 on the image). After this open IDM installation folder ("C:\Program Files (x86)\Internet Download Manager" by default, arrow 4 on the image) and drag and drop "IDMGCExt.crx" (arrow 5 on the image) file into "Extensions" page opened in…